Out of My Mind follows Melody Brooks (newcomer Phoebe-Rae Taylor), a girl with cerebral palsy. Melody has a quick wit and a sharp mind, but due to her being non-verbal and using a wheelchair, she is not given the same academic opportunities as her classmates. However, when Katherine, a young educator notices her student’s untapped potential, she encourages Melody to participate in mainstream education, where greater successes – and challenges – await.